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Deviant kinetochore-microtubule dynamics underlie chromosomal instability

The persistent mal-attachment of microtubules to chromosomes at kinetochores is a major mechanism of chromosomal instability (CIN) [1, 2]. In normal diploid cells, mal-attachments arise spontaneously and are efficiently corrected to preserve genomic stability [3]. However, it is unknown if cancer ce...

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Detalhes bibliográficos
Main Authors: Bakhoum, Samuel F., Genovese, Giulio, Compton, Duane A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2787757/
https://ncbi.nlm.nih.gov/pubmed/19879145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2009.09.055
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