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Deviant kinetochore-microtubule dynamics underlie chromosomal instability
The persistent mal-attachment of microtubules to chromosomes at kinetochores is a major mechanism of chromosomal instability (CIN) [1, 2]. In normal diploid cells, mal-attachments arise spontaneously and are efficiently corrected to preserve genomic stability [3]. However, it is unknown if cancer ce...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2009
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2787757/ https://ncbi.nlm.nih.gov/pubmed/19879145 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2009.09.055 |
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