Islet β-Cell Endoplasmic Reticulum Stress Precedes the Onset of Type 1 Diabetes in the Nonobese Diabetic Mouse Model

Type 1 diabetes is preceded by islet β-cell dysfunction, but the mechanisms leading to β-cell dysfunction have not been rigorously studied. Because immune cell infiltration occurs prior to overt diabetes, we hypothesized that activation of inflammatory cascades and appearance of endoplasmic reticulu...

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Main Authors: Tersey, Sarah A., Nishiki, Yurika, Templin, Andrew T., Cabrera, Susanne M., Stull, Natalie D., Colvin, Stephanie C., Evans-Molina, Carmella, Rickus, Jenna L., Maier, Bernhard, Mirmira, Raghavendra G.
Format: Artigo
Jezik:Inglês
Izdano: American Diabetes Association 2012
Teme:
Islet Studies
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3314371/
https://ncbi.nlm.nih.gov/pubmed/22442300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-1293
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