Increasing Circulating IGFBP1 Levels Improves Insulin Sensitivity, Promotes Nitric Oxide Production, Lowers Blood Pressure, and Protects Against Atherosclerosis

Low concentrations of insulin-like growth factor (IGF) binding protein-1 (IGFBP1) are associated with insulin resistance, diabetes, and cardiovascular disease. We investigated whether increasing IGFBP1 levels can prevent the development of these disorders. Metabolic and vascular phenotype were exami...

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Hauptverfasser: Rajwani, Adil, Ezzat, Vivienne, Smith, Jessica, Yuldasheva, Nadira Y., Duncan, Edward R., Gage, Matthew, Cubbon, Richard M., Kahn, Matthew B., Imrie, Helen, Abbas, Afroze, Viswambharan, Hema, Aziz, Amir, Sukumar, Piruthivi, Vidal-Puig, Antonio, Sethi, Jaswinder K., Xuan, Shouhong, Shah, Ajay M., Grant, Peter J., Porter, Karen E., Kearney, Mark T., Wheatcroft, Stephen B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Diabetes Association 2012
Schlagworte:
Complications
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3314358/
https://ncbi.nlm.nih.gov/pubmed/22357965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-0963
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