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On-line electrochemistry–bioaffinity screening with parallel HR-LC-MS for the generation and characterization of modified p38α kinase inhibitors

In this study, an integrated approach is developed for the formation, identification and biological characterization of electrochemical conversion products of p38α mitogen-activated protein kinase inhibitors. This work demonstrates the hyphenation of an electrochemical reaction cell with a continuou...

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Bibliografske podrobnosti
Main Authors: Falck, David, de Vlieger, Jon S. B., Giera, Martin, Honing, Maarten, Irth, Hubertus, Niessen, Wilfried M. A., Kool, Jeroen
Format: Artigo
Jezik:Inglês
Izdano: Springer-Verlag 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3314180/
https://ncbi.nlm.nih.gov/pubmed/22227812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00216-011-5663-2
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