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On-line electrochemistry–bioaffinity screening with parallel HR-LC-MS for the generation and characterization of modified p38α kinase inhibitors

In this study, an integrated approach is developed for the formation, identification and biological characterization of electrochemical conversion products of p38α mitogen-activated protein kinase inhibitors. This work demonstrates the hyphenation of an electrochemical reaction cell with a continuou...

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Detalhes bibliográficos
Main Authors: Falck, David, de Vlieger, Jon S. B., Giera, Martin, Honing, Maarten, Irth, Hubertus, Niessen, Wilfried M. A., Kool, Jeroen
Formato: Artigo
Idioma:Inglês
Publicado em: Springer-Verlag 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3314180/
https://ncbi.nlm.nih.gov/pubmed/22227812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00216-011-5663-2
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