Development of an online p38α mitogen-activated protein kinase binding assay and integration of LC–HR-MS

A high-resolution screening method was developed for the p38α mitogen-activated protein kinase to detect and identify small-molecule binders. Its central role in inflammatory diseases makes this enzyme a very important drug target. The setup integrates separation by high-performance liquid chromatog...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Falck, David, de Vlieger, Jon S. B., Niessen, Wilfried M. A., Kool, Jeroen, Honing, Maarten, Giera, Martin, Irth, Hubertus
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Springer-Verlag 2010
Aiheet:
Original Paper
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2943585/
https://ncbi.nlm.nih.gov/pubmed/20730527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00216-010-4087-8
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