On-line electrochemistry–bioaffinity screening with parallel HR-LC-MS for the generation and characterization of modified p38α kinase inhibitors

In this study, an integrated approach is developed for the formation, identification and biological characterization of electrochemical conversion products of p38α mitogen-activated protein kinase inhibitors. This work demonstrates the hyphenation of an electrochemical reaction cell with a continuou...

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Detalles Bibliográficos
Main Authors: Falck, David, de Vlieger, Jon S. B., Giera, Martin, Honing, Maarten, Irth, Hubertus, Niessen, Wilfried M. A., Kool, Jeroen
Formato: Artigo
Idioma:Inglês
Publicado: Springer-Verlag 2012
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Original Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3314180/
https://ncbi.nlm.nih.gov/pubmed/22227812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00216-011-5663-2
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