Some phorbol esters may partially resemble bryostatin 1 in their actions on LNCaP prostate cancer cells and U937 leukemia cells

Phorbol 12-myristate 13-acetate (PMA) and bryostatin 1 are both potent protein kinase C (PKC) activators. In LNCaP human prostate cancer cells, PMA induces tumor necrosis factor alpha (TNFα) secretion and inhibits proliferation; bryostatin 1 does not and itself blocks the response to PMA. This diffe...

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Autores principales: Kedei, Noemi, Lubart, Emanuel, Lewin, Nancy E., Telek, Andrea, Lim, Langston, Mannan, Poonam, Garfield, Susan H., Kraft, Matthew B., Keck, Gary E., Kolusheva, Sofiya, Jelinek, Raz, Blumberg, Peter M.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3313843/
https://ncbi.nlm.nih.gov/pubmed/21542090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201100064
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