Azalysine Analogs as Probes for Protein Lysine Deacetylation and Demethylation

Reversible lysine acetylation and methylation regulate the function of a wide variety of proteins, including histones. Here we have synthesized azalysine-containing peptides in acetylated and unacetylated forms as chemical probes of the histone deacetylases (HDAC8, Sir2Tm, and SIRT1) and the histone...

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Detalhes bibliográficos
Main Authors: Dancy, Blair C. R., Ming, Shonoi A., Papazyan, Romeo, Jelinek, Christine A., Majumdar, Ananya, Sun, Yan, Dancy, Beverley M., Drury, William J., Cotter, Robert J., Taverna, Sean D., Cole, Philip A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3313494/
https://ncbi.nlm.nih.gov/pubmed/22352831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja209574z
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