Complex phenotypes in mosquitoes and mice associated with neutralization escape of a Dengue virus type 1 monoclonal antibody

DENV1-E106 is a monoclonal antibody (MAb) with strong neutralizing activity against all five DENV-1 genotypes and therapeutic activity in mice. Here, we evaluated the potential for DENV-1 to escape neutralization by DENV1-E106. A single mutation in domain III of the envelope protein (T329A) emerged,...

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Main Authors: Shrestha, Bimmi, Austin, S. Kyle, Dowd, Kimberly A., Prasad, Abhishek N., Youn, Soonjeon, Pierson, Theodore C., Fremont, Daved H., Ebel, Gregory D., Diamond, Michael. S.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3312934/
https://ncbi.nlm.nih.gov/pubmed/22406169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2012.02.010
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