The HR2 polymorphism N140I in the HIV-1 gp41 combined with the HR1 V38A mutation is associated with a less cytopathic phenotype

BACKGROUND: Resistance to the fusion inhibitor enfuvirtide (ENF) is achieved by changes in the gp41 subunit of the HIV envelope glycoprotein (Env). Specific ENF-associated mutational pathways correlate with immunological recovery, even after virological failure, suggesting that the acquisition of EN...

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Hauptverfasser: Cunyat, Francesc, Marfil, Silvia, García, Elisabet, Svicher, Valentina, Pérez-Alvárez, Nuria, Curriu, Marta, Perno, Carlo Federico, Clotet, Bonaventura, Blanco, Julià, Cabrera, Cecilia
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2012
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3312827/
https://ncbi.nlm.nih.gov/pubmed/22333046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-9-15
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