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Interactions of HIV-1 Inhibitory Peptide T20 with the gp41 N-HR Coiled Coil

Cellular entry of human immunodeficiency virus type 1 (HIV-1) involves fusion of viral and cellular membranes and is mediated by structural transitions in viral glycoprotein gp41. The antiviral C-peptide T20 targets the gp41 N-terminal heptad repeat region (N-HR), blocking gp41 conformational change...

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Autori principali: Champagne, Kelly, Shishido, Akira, Root, Michael J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2635040/
https://ncbi.nlm.nih.gov/pubmed/19073602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M809269200
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