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Transient depletion of B cells in young mice results in activation of regulatory T cells that inhibit development of autoimmune disease in adults
B-cell depletion therapy can be effective for treating B-cell lymphomas as well as many human and murine autoimmune diseases. B-cell-deficient mice are normally resistant to spontaneous autoimmune thyroiditis (SAT), but they develop SAT if regulatory T cells are transiently depleted during the first...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3312073/ https://ncbi.nlm.nih.gov/pubmed/22298883 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/intimm/dxs003 |
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