Transient Low Doses of DNA Demethylating Agents Exert Durable Anti-tumor Effects on Hematological and Epithelial Tumor Cells

Reversal of promoter DNA hypermethylation and associated gene silencing is an attractive cancer therapy approach. The DNA methylation inhibitors decitabine and azacitidine are efficacious for hematological neoplasms at lower, less toxic, doses. Experimentally, high doses induce rapid DNA damage and...

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主要な著者: Tsai, Hsing-Chen, Li, Huili, Van Neste, Leander, Cai, Yi, Robert, Carine, Rassool, Feyruz V., Shin, James J., Harbom, Kirsten M., Beaty, Robert, Pappou, Emmanouil, Harris, James, Yen, Ray-Whay Chiu, Ahuja, Nita, Brock, Malcolm V., Stearns, Vered, Feller-Kopman, David, Yarmus, Lonny B., Lin, Yi-Chun, Welm, Alana L., Issa, Jean-Pierre, Minn, Il, Matsui, William, Jang, Yoon-Young, Sharkis, Saul J., Baylin, Stephen B., Zahnow, Cynthia A.
フォーマット: Artigo
言語:Inglês
出版事項: 2012
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3312044/
https://ncbi.nlm.nih.gov/pubmed/22439938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2011.12.029
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