Transient Low Doses of DNA Demethylating Agents Exert Durable Anti-tumor Effects on Hematological and Epithelial Tumor Cells

Reversal of promoter DNA hypermethylation and associated gene silencing is an attractive cancer therapy approach. The DNA methylation inhibitors decitabine and azacitidine are efficacious for hematological neoplasms at lower, less toxic, doses. Experimentally, high doses induce rapid DNA damage and...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Tsai, Hsing-Chen, Li, Huili, Van Neste, Leander, Cai, Yi, Robert, Carine, Rassool, Feyruz V., Shin, James J., Harbom, Kirsten M., Beaty, Robert, Pappou, Emmanouil, Harris, James, Yen, Ray-Whay Chiu, Ahuja, Nita, Brock, Malcolm V., Stearns, Vered, Feller-Kopman, David, Yarmus, Lonny B., Lin, Yi-Chun, Welm, Alana L., Issa, Jean-Pierre, Minn, Il, Matsui, William, Jang, Yoon-Young, Sharkis, Saul J., Baylin, Stephen B., Zahnow, Cynthia A.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2012
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3312044/
https://ncbi.nlm.nih.gov/pubmed/22439938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2011.12.029
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