Targeting of Histone Acetyltransferase p300 by Cyclopentenone Prostaglandin Δ(12)-PGJ(2) through Covalent Binding to Cys(1438)

[Image: see text] Inhibitors of histone acetyltransferases (HATs) are perceived to treat diseases like cancer, neurodegeneration, and AIDS. On the basis of previous studies, we hypothesized that Cys(1438) in the substrate binding site could be targeted by Δ(12)-prostaglandin J(2) (Δ(12)-PGJ(2)), a c...

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Main Authors: Ravindra, Kodihalli C., Narayan, Vivek, Lushington, Gerald H., Peterson, Blake R., Prabhu, K. Sandeep
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3312006/
https://ncbi.nlm.nih.gov/pubmed/22141352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx200383c
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