Inhibition of cytochrome P4501-dependent clearance of the endogenous agonist FICZ as a mechanism for activation of the aryl hydrocarbon receptor

Altered systemic levels of 6-formylindolo[3,2-b]carbazole (FICZ), an enigmatic endogenous ligand for the aryl hydrocarbon receptor (AHR), may explain adverse physiological responses evoked by small natural and anthropogenic molecules as well as by oxidative stress and light. We demonstrate here that...

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Bibliographische Detailangaben
Hauptverfasser: Wincent, Emma, Bengtsson, Johanna, Bardbori, Afshin Mohammadi, Alsberg, Tomas, Luecke, Sandra, Rannug, Ulf, Rannug, Agneta
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2012
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3311358/
https://ncbi.nlm.nih.gov/pubmed/22392998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1118467109
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