Inhibition of cytochrome P4501-dependent clearance of the endogenous agonist FICZ as a mechanism for activation of the aryl hydrocarbon receptor

Altered systemic levels of 6-formylindolo[3,2-b]carbazole (FICZ), an enigmatic endogenous ligand for the aryl hydrocarbon receptor (AHR), may explain adverse physiological responses evoked by small natural and anthropogenic molecules as well as by oxidative stress and light. We demonstrate here that...

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Bibliografiska uppgifter
Huvudupphovsmän: Wincent, Emma, Bengtsson, Johanna, Bardbori, Afshin Mohammadi, Alsberg, Tomas, Luecke, Sandra, Rannug, Ulf, Rannug, Agneta
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2012
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3311358/
https://ncbi.nlm.nih.gov/pubmed/22392998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1118467109
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