Promiscuous binding of extracellular peptides to cell surface class I MHC protein

Algorithms derived from measurements of short-peptide (8–10 mers) binding to class I MHC proteins suggest that the binding groove of a class I MHC protein, such as K(b), can bind well over 1 million different peptides with significant affinity (<500 nM), a level of ligand-binding promiscuity appr...

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Detalhes bibliográficos
Main Authors: Eisen, Herman N., Hou, Xun Helen, Shen, Chase, Wang, Kaidi, Tanguturi, Varsha Keelara, Smith, Crysela, Kozyrytska, Katerina, Nambiar, Lakshmi, McKinley, Carol A., Chen, Jianzhu, Cohen, Richard J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3311345/
https://ncbi.nlm.nih.gov/pubmed/22403068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1201586109
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