Soluble peptide–MHC monomers cause activation of CD8(+) T cells through transfer of the peptide to T cell MHC molecules

T cell receptor (TCR)-mediated activation of CD4(+) T cells is known to require multivalent engagement of the TCR by, for example, oligomeric peptide–MHC complexes. In contrast, for CD8(+) T cells, there is evidence for TCR-mediated activation by univalent engagement of the TCR. We have here compare...

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Bibliographische Detailangaben
Hauptverfasser: Ge, Qing, Stone, Jennifer D., Thompson, M. Todd, Cochran, Jennifer R., Rushe, Mia, Eisen, Herman N., Chen, Jianzhu, Stern, Lawrence J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The National Academy of Sciences 2002
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC129758/
https://ncbi.nlm.nih.gov/pubmed/12374859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.212515299
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