Antiproliferative small-molecule inhibitors of transcription factor LSF reveal oncogene addiction to LSF in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide. Despite the prevalence of HCC, there is no effective, systemic treatment. The transcription factor LSF is a promising protein target for chemotherapy; it is highly expressed in HCC patient samples and cell lines, and promotes...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Grant, Trevor J., Bishop, Joshua A., Christadore, Lisa M., Barot, Girish, Chin, Hang Gyeong, Woodson, Sarah, Kavouris, John, Siddiq, Ayesha, Gredler, Rachel, Shen, Xue-Ning, Sherman, Jennifer, Meehan, Tracy, Fitzgerald, Kevin, Pradhan, Sriharsa, Briggs, Laura A., Andrews, William H., Sarkar, Devanand, Schaus, Scott E., Hansen, Ulla
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: National Academy of Sciences 2012
Θέματα:
Biological Sciences
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3311344/
https://ncbi.nlm.nih.gov/pubmed/22396589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1121601109
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