Antiproliferative small-molecule inhibitors of transcription factor LSF reveal oncogene addiction to LSF in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide. Despite the prevalence of HCC, there is no effective, systemic treatment. The transcription factor LSF is a promising protein target for chemotherapy; it is highly expressed in HCC patient samples and cell lines, and promotes...

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Detalhes bibliográficos
Main Authors: Grant, Trevor J., Bishop, Joshua A., Christadore, Lisa M., Barot, Girish, Chin, Hang Gyeong, Woodson, Sarah, Kavouris, John, Siddiq, Ayesha, Gredler, Rachel, Shen, Xue-Ning, Sherman, Jennifer, Meehan, Tracy, Fitzgerald, Kevin, Pradhan, Sriharsa, Briggs, Laura A., Andrews, William H., Sarkar, Devanand, Schaus, Scott E., Hansen, Ulla
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3311344/
https://ncbi.nlm.nih.gov/pubmed/22396589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1121601109
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