Antiproliferative small-molecule inhibitors of transcription factor LSF reveal oncogene addiction to LSF in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide. Despite the prevalence of HCC, there is no effective, systemic treatment. The transcription factor LSF is a promising protein target for chemotherapy; it is highly expressed in HCC patient samples and cell lines, and promotes...

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Autors principals: Grant, Trevor J., Bishop, Joshua A., Christadore, Lisa M., Barot, Girish, Chin, Hang Gyeong, Woodson, Sarah, Kavouris, John, Siddiq, Ayesha, Gredler, Rachel, Shen, Xue-Ning, Sherman, Jennifer, Meehan, Tracy, Fitzgerald, Kevin, Pradhan, Sriharsa, Briggs, Laura A., Andrews, William H., Sarkar, Devanand, Schaus, Scott E., Hansen, Ulla
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2012
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3311344/
https://ncbi.nlm.nih.gov/pubmed/22396589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1121601109
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