Antiproliferative small-molecule inhibitors of transcription factor LSF reveal oncogene addiction to LSF in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide. Despite the prevalence of HCC, there is no effective, systemic treatment. The transcription factor LSF is a promising protein target for chemotherapy; it is highly expressed in HCC patient samples and cell lines, and promotes...

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Bibliographische Detailangaben
Hauptverfasser: Grant, Trevor J., Bishop, Joshua A., Christadore, Lisa M., Barot, Girish, Chin, Hang Gyeong, Woodson, Sarah, Kavouris, John, Siddiq, Ayesha, Gredler, Rachel, Shen, Xue-Ning, Sherman, Jennifer, Meehan, Tracy, Fitzgerald, Kevin, Pradhan, Sriharsa, Briggs, Laura A., Andrews, William H., Sarkar, Devanand, Schaus, Scott E., Hansen, Ulla
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2012
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3311344/
https://ncbi.nlm.nih.gov/pubmed/22396589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1121601109
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