Transcription factor LSF-DNMT1 complex dissociation by FQI1 leads to aberrant DNA methylation and gene expression

The transcription factor LSF is highly expressed in hepatocellular carcinoma (HCC) and promotes oncogenesis. Factor quinolinone inhibitor 1 (FQI1), inhibits LSF DNA-binding activity and exerts anti-proliferative activity. Here, we show that LSF binds directly to the maintenance DNA (cytosine-5) meth...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Chin, Hang Gyeong, Ponnaluri, V.K. Chaithanya, Zhang, Guoqiang, Estève, Pierre-Olivier, Schaus, Scott E., Hansen, Ulla, Pradhan, Sriharsa
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5347793/
https://ncbi.nlm.nih.gov/pubmed/27845898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.13271
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