Binding of 14-3-3 reader proteins to phosphorylated DNMT1 facilitates aberrant DNA methylation and gene expression

Mammalian DNA (cytosine-5) methyltransferase 1 (DNMT1) is essential for maintenance methylation. Phosphorylation of Ser143 (pSer143) stabilizes DNMT1 during DNA replication. Here, we show 14-3-3 is a reader protein of DNMT1pSer143. In mammalian cells 14-3-3 colocalizes and binds DNMT1pSer143 post-DN...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Estève, Pierre-Olivier, Zhang, Guoqiang, Ponnaluri, V.K. Chaithanya, Deepti, Kanneganti, Chin, Hang Gyeong, Dai, Nan, Sagum, Cari, Black, Karynne, Corrêa, Ivan R., Bedford, Mark T., Cheng, Xiaodong, Pradhan, Sriharsa
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Gene regulation, Chromatin and Epigenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4770214/
https://ncbi.nlm.nih.gov/pubmed/26553800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv1162
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