Sonic Hedgehog-activated engineered blood vessels enhance bone tissue formation

Large bone defects naturally regenerate via a highly vascularized tissue which progressively remodels into cartilage and bone. Current approaches in bone tissue engineering are restricted by delayed vascularization and fail to recapitulate this stepwise differentiation toward bone tissue. Here, we u...

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Bibliographische Detailangaben
Hauptverfasser: Rivron, Nicolas C., Raiss, Christian C., Liu, Jun, Nandakumar, Anandkumar, Sticht, Carsten, Gretz, Norbert, Truckenmüller, Roman, Rouwkema, Jeroen, van Blitterswijk, Clemens A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2012
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3311342/
https://ncbi.nlm.nih.gov/pubmed/22388744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1117627109
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