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Instability of (CTG)(n)•(CAG)(n )trinucleotide repeats and DNA synthesis
Expansion of (CTG)(n)•(CAG)(n )trinucleotide repeat (TNR) microsatellite sequences is the cause of more than a dozen human neurodegenerative diseases. (CTG)(n )and (CAG)(n )repeats form imperfectly base paired hairpins that tend to expand in vivo in a length-dependent manner. Yeast, mouse and human...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
BioMed Central
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3310812/ https://ncbi.nlm.nih.gov/pubmed/22369689 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2045-3701-2-7 |
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