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Altered Replication in Human Cells Promotes DMPK (CTG)(n) · (CAG)(n) Repeat Instability
Myotonic dystrophy type 1 (DM1) is associated with expansion of (CTG)(n) · (CAG)(n) trinucleotide repeats (TNRs) in the 3′ untranslated region (UTR) of the DMPK gene. Replication origins are cis-acting elements that potentiate TNR instability; therefore, we mapped replication initiation sites and pr...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Microbiology
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3347245/ https://ncbi.nlm.nih.gov/pubmed/22354993 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.06727-11 |
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