PTPN2 Gene Variants Are Associated with Susceptibility to Both Crohn's Disease and Ulcerative Colitis Supporting a Common Genetic Disease Background

BACKGROUND: Genome-wide association studies identified PTPN2 (protein tyrosine phosphatase, non-receptor type 2) as susceptibility gene for inflammatory bowel diseases (IBD). However, the exact role of PTPN2 in Crohn's disease (CD) and ulcerative colitis (UC) and its phenotypic effect are uncle...

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Hauptverfasser: Glas, Jürgen, Wagner, Johanna, Seiderer, Julia, Olszak, Torsten, Wetzke, Martin, Beigel, Florian, Tillack, Cornelia, Stallhofer, Johannes, Friedrich, Matthias, Steib, Christian, Göke, Burkhard, Ochsenkühn, Thomas, Karbalai, Nazanin, Diegelmann, Julia, Czamara, Darina, Brand, Stephan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3310077/
https://ncbi.nlm.nih.gov/pubmed/22457781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0033682
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