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PTPN2 Gene Variants Are Associated with Susceptibility to Both Crohn's Disease and Ulcerative Colitis Supporting a Common Genetic Disease Background

BACKGROUND: Genome-wide association studies identified PTPN2 (protein tyrosine phosphatase, non-receptor type 2) as susceptibility gene for inflammatory bowel diseases (IBD). However, the exact role of PTPN2 in Crohn's disease (CD) and ulcerative colitis (UC) and its phenotypic effect are uncle...

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Bibliografske podrobnosti
Main Authors: Glas, Jürgen, Wagner, Johanna, Seiderer, Julia, Olszak, Torsten, Wetzke, Martin, Beigel, Florian, Tillack, Cornelia, Stallhofer, Johannes, Friedrich, Matthias, Steib, Christian, Göke, Burkhard, Ochsenkühn, Thomas, Karbalai, Nazanin, Diegelmann, Julia, Czamara, Darina, Brand, Stephan
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3310077/
https://ncbi.nlm.nih.gov/pubmed/22457781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0033682
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