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Intact function of Lgr5 receptor-expressing intestinal stem cells in the absence of Paneth cells
Lifelong self-renewal of the adult intestinal epithelium requires the activity of stem cells located in mucosal crypts. Lgr5 and Bmi1 are two molecular markers of crypt-cell populations that replenish all lineages over time and hence function as stem cells. Intestinal stem cells require Wnt signalin...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
2012
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3309789/ https://ncbi.nlm.nih.gov/pubmed/22355124 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1113890109 |
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