The protein kinase Akt1 regulates the interferon response through phosphorylation of the transcriptional repressor EMSY

The protein kinases Akt1, Akt2, and Akt3 possess nonredundant signaling properties, few of which have been investigated. Here, we present evidence for an Akt1-dependent pathway that controls interferon (IFN)-regulated gene expression and antiviral immunity. The target of this pathway is EMSY, an onc...

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Bibliografiska uppgifter
Huvudupphovsmän: Ezell, Scott A., Polytarchou, Christos, Hatziapostolou, Maria, Guo, Ailan, Sanidas, Ioannis, Bihani, Teeru, Comb, Michael J., Sourvinos, George, Tsichlis, Philip N.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2012
Ämnen:
PNAS Plus
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3309773/
https://ncbi.nlm.nih.gov/pubmed/22315412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1115029109
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