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Akt3 induces oxidative stress and DNA damage by activating the NADPH oxidase via phosphorylation of p47(phox)
Akt activation up-regulates the intracellular levels of reactive oxygen species (ROS) by inhibiting ROS scavenging. Of the Akt isoforms, Akt3 has also been shown to up-regulate ROS by promoting mitochondrial biogenesis. Here, we employ a set of isogenic cell lines that express different Akt isoforms...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7682348/ https://ncbi.nlm.nih.gov/pubmed/33139577 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2017830117 |
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