Modulation of p47(PHOX) activity by site-specific phosphorylation: Akt-dependent activation of the NADPH oxidase

The leukocyte NADPH oxidase catalyzes the reduction of oxygen to O [Formula: see text] at the expense of NADPH. Extensive phosphorylation of the oxidase subunit p47(PHOX) occurs during the activation of the enzyme in intact cells. p47(PHOX) carrying certain serine-to-alanine mutations fails to suppo...

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Bibliografiska uppgifter
Huvudupphovsmän: Hoyal, Carolyn R., Gutierrez, Abel, Young, Brandon M., Catz, Sergio D., Lin, Jun-Hsiang, Tsichlis, Philip N., Babior, Bernard M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The National Academy of Sciences 2003
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC154310/
https://ncbi.nlm.nih.gov/pubmed/12704229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1031526100
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