Modulation of p47(PHOX) activity by site-specific phosphorylation: Akt-dependent activation of the NADPH oxidase

The leukocyte NADPH oxidase catalyzes the reduction of oxygen to O [Formula: see text] at the expense of NADPH. Extensive phosphorylation of the oxidase subunit p47(PHOX) occurs during the activation of the enzyme in intact cells. p47(PHOX) carrying certain serine-to-alanine mutations fails to suppo...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Hoyal, Carolyn R., Gutierrez, Abel, Young, Brandon M., Catz, Sergio D., Lin, Jun-Hsiang, Tsichlis, Philip N., Babior, Bernard M.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2003
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC154310/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12704229/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.1031526100
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