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Diverse recognition of non-PxxP peptide ligands by the SH3 domains from p67(phox), Grb2 and Pex13p

The basic function of the Src homology 3 (SH3) domain is considered to be binding to proline-rich sequences containing a PxxP motif. Recently, many SH3 domains, including those from Grb2 and Pex13p, were reported to bind sequences lacking a PxxP motif. We report here that the 22 residue peptide lack...

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Detalhes bibliográficos
Main Authors: Kami, Keiichiro, Takeya, Ryu, Sumimoto, Hideki, Kohda, Daisuke
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC126167/
https://ncbi.nlm.nih.gov/pubmed/12169629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdf428
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