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Negative feedback confers mutational robustness in yeast transcription factor regulation

Organismal fitness depends on the ability of gene networks to function robustly in the face of environmental and genetic perturbations. Understanding the mechanisms of this stability is one of the key aims of modern systems biology. Dissecting the basis of robustness to mutation has proven a particu...

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Sonraí Bibleagrafaíochta
Main Authors: Denby, Charles M., Im, Joo Hyun, Yu, Richard C., Pesce, C. Gustavo, Brem, Rachel B.
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2012
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3309721/
https://ncbi.nlm.nih.gov/pubmed/22355134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1116360109
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