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The Amyloid Precursor Protein Forms Plasmalemmal Clusters via Its Pathogenic Amyloid-β Domain
The amyloid precursor protein (APP) is a large, ubiquitous integral membrane protein with a small amyloid-β (Aβ) domain. In the human brain, endosomal processing of APP produces neurotoxic Aβ-peptides, which are involved in Alzheimer's disease. Here, we show that the Aβ sequence exerts a physio...
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| Auteurs principaux: | , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
The Biophysical Society
2012
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3309305/ https://ncbi.nlm.nih.gov/pubmed/22455924 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2012.02.031 |
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