Effects of Angiopoietin-2-Blocking Antibody on Endothelial Cell–Cell Junctions and Lung Metastasis

BACKGROUND: Angiopoietin-2 (Ang2), a ligand for endothelial TEK (Tie2) tyrosine kinase receptor, is induced in hypoxic endothelial cells of tumors, where it promotes tumor angiogenesis and growth. However, the effects of Ang2 on tumor lymphangiogenesis and metastasis are poorly characterized. METHOD...

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Main Authors: Holopainen, Tanja, Saharinen, Pipsa, D’Amico, Gabriela, Lampinen, Anita, Eklund, Lauri, Sormunen, Raija, Anisimov, Andrey, Zarkada, Georgia, Lohela, Marja, Heloterä, Hanna, Tammela, Tuomas, Benjamin, Laura E., Ylä-Herttuala, Seppo, Leow, Ching Ching, Koh, Gou Young, Alitalo, Kari
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2012
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3309130/
https://ncbi.nlm.nih.gov/pubmed/22343031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djs009
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