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A Mechanism Underlying NOTCH-Induced and Ubiquitin-mediated JAK3 Degradation
Although NOTCH signaling is well known to regulate lymphopoiesis, Janus kinase 3 (JAK3) also plays a critical role in promoting lymphocyte development. We have previously found that NOTCH signaling leads to the degradation of JAK3 in B lineage cells, suggesting that NOTCH signaling exerts its biolog...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2011
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3308829/ https://ncbi.nlm.nih.gov/pubmed/21969365 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.273755 |
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