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Notch-induced E2A ubiquitination and degradation are controlled by MAP kinase activities
Notch signals are important for lymphocyte development but downstream events that follow Notch signaling are not well understood. Here, we report that signaling through Notch modulates the turnover of E2A proteins including E12 and E47, which are basic helix–loop–helix proteins crucial for B and T l...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2003
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC275424/ https://ncbi.nlm.nih.gov/pubmed/14592976 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg567 |
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