Human Mitochondrial DNA Polymerase γ Exhibits Potential for Bypass and Mutagenesis at UV-induced Cyclobutane Thymine Dimers

Cyclobutane thymine dimers (T-T) comprise the majority of DNA damage caused by short wavelength ultraviolet radiation. These lesions generally block replicative DNA polymerases and are repaired by nucleotide excision repair or bypassed by translesion polymerases in the nucleus. Mitochondria lack nuc...

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Hauptverfasser: Kasiviswanathan, Rajesh, Gustafson, Margaret A., Copeland, William C., Meyer, Joel N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2012
Schlagworte:
DNA and Chromosomes
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3308766/
https://ncbi.nlm.nih.gov/pubmed/22194617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.306852
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