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A fungal ketoreductase domain that displays substrate-dependent stereospecificity
Iterative highly-reducing polyketide synthases (HR-PKSs) from filamentous fungi are the most complex and enigmatic type of PKS discovered to date. Here we uncover an unusual level of programming by the hypothemycin HR-PKS, in which a single ketoreductase domain displays stereospecificity that is con...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3307869/ https://ncbi.nlm.nih.gov/pubmed/22406519 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.912 |
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