Potential Drug Abuse Therapeutics Derived from the Hallucinogenic Natural Product Salvinorin A

Previous structure-activity relationship studies of salvinorin A have shown that modification of the acetate functionality off the C-2 position to a methoxy methyl or methoxy ethyl ether moiety leads to increased potency at KOP receptors. However, the reason for this increase remains unclear. Here w...

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Main Authors: Prevatt-Smith, Katherine M., Lovell, Kimberly M., Simpson, Denise S., Day, Victor W., Douglas, Justin T., Bosch, Peter, Dersch, Christina M., Rothman, Richard B., Kivell, Bronwyn, Prisinzano, Thomas E.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3307802/
https://ncbi.nlm.nih.gov/pubmed/22442751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C1MD00192B
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