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Indirect inhibition of 26S proteasome activity in a cellular model of Huntington’s disease
Pathognomonic accumulation of ubiquitin (Ub) conjugates in human neurodegenerative diseases, such as Huntington’s disease, suggests that highly aggregated proteins interfere with 26S proteasome activity. In this paper, we examine possible mechanisms by which an N-terminal fragment of mutant huntingt...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The Rockefeller University Press
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3307690/ https://ncbi.nlm.nih.gov/pubmed/22371559 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201110093 |
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