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Synthesis and Evaluation of 17α-(Dimethylphenyl)vinyl Estradiols as Probes of the Estrogen Receptor-α Ligand Binding Domain
As part of our program to explore the influence of small structural modifications on the biological response of the estrogen receptor-α (ERα), we prepared and evaluated a series of mono-and di-substituted phenyl vinyl estradiols. The target compounds were prepared in 45 -80 % yields using the Stille...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3307546/ https://ncbi.nlm.nih.gov/pubmed/22273809 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.steroids.2012.01.003 |
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