Synthesis and Evaluation of 17α-(Dimethylphenyl)vinyl Estradiols as Probes of the Estrogen Receptor-α Ligand Binding Domain

As part of our program to explore the influence of small structural modifications on the biological response of the estrogen receptor-α (ERα), we prepared and evaluated a series of mono-and di-substituted phenyl vinyl estradiols. The target compounds were prepared in 45 -80 % yields using the Stille...

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Main Authors: Hanson, Robert N., McCaskill, Emmett, Tongcharoensirikul, Pakamas, Dilis, Robert, Labaree, David, Hochberg, Richard B.
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3307546/
https://ncbi.nlm.nih.gov/pubmed/22273809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.steroids.2012.01.003
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