Synthesis and evaluation of 17α-E-20-(heteroaryl)norpregn-1,3,5(10),20 tetraene-3,17β-diols [17α- (heteroaryl)vinyl estradiols] as ligands for the estrogen receptor-α-ligand binding domain (ERα-LBD)

A series of 17α- (heteroaryl)vinyl estradiols was prepared to evaluate the influence of heteroatom on the affinity and efficacy of estrogenic ligands for the estrogen receptor-alpha ligand binding domain (ERα-LBD). The products demonstrated reduced binding affinity compared to the parent 17α-E-pheny...

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Hoofdauteurs: Olmsted, Sandra L., Tongcharoensirikul, Pakamas, McCaskill, Emmett, Gandiaga, Karla, Labaree, David, Hochberg, Richard B., Hanson, Robert N.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2011
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3259610/
https://ncbi.nlm.nih.gov/pubmed/22178552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2011.12.003
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