Dwarfism in Mice Lacking Collagen-binding Integrins α2β1 and α11β1 Is Caused by Severely Diminished IGF-1 Levels

Mice with a combined deficiency in the α2β1 and α11β1 integrins lack the major receptors for collagen I. These mutants are born with inconspicuous differences in size but develop dwarfism within the first 4 weeks of life. Dwarfism correlates with shorter, less mineralized and functionally weaker bon...

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Detalhes bibliográficos
Main Authors: Blumbach, Katrin, Niehoff, Anja, Belgardt, Bengt F., Ehlen, Harald W. A., Schmitz, Markus, Hallinger, Ralf, Schulz, Jan-Niklas, Brüning, Jens C., Krieg, Thomas, Schubert, Markus, Gullberg, Donald, Eckes, Beate
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Glycobiology and Extracellular Matrices
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3307312/
https://ncbi.nlm.nih.gov/pubmed/22210772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.283119
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